Botox vs Dysport vs Daxxify vs Xeomin — How to Choose

Botox is the brand name everyone knows, but it isn’t the only FDA-approved neurotoxin available in the US. As of 2026, five products compete for the same wrinkle-treatment market: Botox Cosmetic (Allergan), Dysport (Galderma), Xeomin (Merz), Jeuveau (Evolus), and Daxxify (Revance). They share a mechanism — they all temporarily block muscle contraction by interfering with acetylcholine release — but they are not interchangeable.

Here’s what differs and why it matters.

The five products at a glance

Product	Maker	FDA approval (cosmetic)	Typical onset	Typical duration	Price per unit (US)
Botox Cosmetic	Allergan/AbbVie	2002 (glabellar)	3–5 days	3–4 months	$11–$20
Dysport	Galderma	2009	2–3 days	3–4 months	$4–$7*
Xeomin	Merz	2011	3–5 days	3–4 months	$10–$18
Jeuveau (“Newtox”)	Evolus	2019	2–3 days	3–4 months	$8–$14
Daxxify	Revance	2022	1–2 days	6 months claimed	$20–$30

*Dysport’s per-unit pricing isn’t directly comparable to the others — Dysport units are smaller. A typical glabellar treatment uses ~50 Dysport units vs ~20 Botox units. Total session cost ends up similar.

How they actually differ

Onset (when results appear)

Dysport and Jeuveau are the fastest off the line — many patients see softening of fine lines within 48–72 hours. Botox typically takes 3–5 days for visible effect and 7–14 days for full effect. Daxxify is the new entrant claiming the fastest onset at 1–2 days, supported by its Phase III trial data.

This matters most for time-sensitive bookings: weddings, public-facing presentations, photo shoots. If you’re treating exactly 7 days out, Dysport gives you a buffer.

Duration

Daxxify is the duration outlier. Revance’s trials reported 6-month average duration, roughly double Botox and Dysport’s 3–4 months. The trade-off: Daxxify is the most expensive per session, and the 6-month claim is based on a single Phase III endpoint that defines “duration” generously. Real-world duration reports from injectors and patients land closer to 4–5 months on average, still meaningfully longer than Botox.

Botox, Dysport, Jeuveau, and Xeomin sit close together on duration — typically 3–4 months for the glabellar lines, sometimes shorter at higher-mobility sites like the lower face.

Spread / diffusion

Dysport has slightly larger zone of spread per injection point than Botox, which can be an advantage for treating larger, flatter areas (forehead, large masseters) but a disadvantage in high-precision work (lip flip, very thin patients). Skilled injectors compensate by adjusting injection technique, but the underlying physics differ.

Xeomin is a “naked” formulation — it lacks the surrounding proteins that Botox and Dysport carry, which Merz argues reduces the chance of developing neutralising antibodies over time. Whether antibody-mediated resistance is a meaningful real-world concern at typical cosmetic doses is still debated.

Price per session

Per-unit pricing is not comparable across products (different unit definitions). What matters is total session cost for an equivalent treatment:

• Glabellar lines (the ”11s”): typically $200–$450 across all four traditional products.
• Daxxify: usually 25–40% more per session, justified to patients by the longer duration.

If you treat 3 times per year with Botox at $300/session = $900/year. If Daxxify lasts 5 months on average, you might treat 2.4 times per year at $400 = $960/year. Comparable annual cost, fewer appointments.

Which one is right for you?

First-time patient: Botox or Dysport. Most predictable response, widest injector experience, easiest to course-correct if you don’t like the result.

Sensitive to “frozen” look: Botox (smaller spread) or Xeomin (more naked formulation, easier to dose precisely). Avoid Dysport for high-precision areas if you can’t find an experienced Dysport-specific injector.

Need fast onset: Dysport, Jeuveau, or Daxxify.

Hate frequent appointments: Daxxify. The longer duration is real, even if not quite the 6-month claim.

Concerned about antibody resistance: Xeomin is the only one without complexing proteins. Relevance for typical cosmetic doses is debatable but the option exists.

Best loyalty rewards: Allergan’s Allē program (Botox, Juvederm) is the largest US aesthetic loyalty platform — saves repeat patients 10–15% per session on Allergan products and offers points across Allergan’s broader portfolio. Galderma’s ASPIRE program (Dysport, Restylane) is the main competitor. Daxxify’s Revance loyalty program is newer but growing.

What doesn’t matter (much)

Country of origin / manufacturer marketing. All five products are FDA-approved, with comparable safety profiles when administered correctly. Galderma is Swiss, Revance is American, Allergan was Irish (now part of AbbVie), Merz is German, Evolus is American with Korean-manufactured product. This is interesting trivia, not a clinical signal.

“Natural” vs “synthetic” framing. All five are biologic products purified from bacterial fermentation. None are more natural than the others.

Per-unit price compared across products. Unit definitions differ. Compare per-session cost or per-month cost for the same outcome.

What matters most: the injector

Across all five products, the injector’s skill is the dominant variable. A great injector with Botox produces better results than an average injector with Daxxify. Verify credentials, look at before/after work, and prioritise consistent technique over which brand the clinic stocks.

To find a vetted injector near you, see our directory:

• Botox providers in Miami
• Best Botox in Miami 2026 — editorial picks

Sources & references

For procedure-specific patient information from manufacturers:

• Botox Cosmetic (Allergan/AbbVie)
• Dysport (Galderma)
• Daxxify (Revance)
• Xeomin (Merz Aesthetics)
• Jeuveau (Evolus)

This article is editorial. Medical Spa Reviews is not a medical resource. Confirm any procedure decision with a licensed injector.